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Pediatr Res. 2005 May;57(5 Pt 2):110R-117R. Epub 2005 Apr 6.

Potential for protection and repair following injury to the developing brain: a role for erythropoietin?

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1
Division of Neonatal-Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA. asola2@emory.edu

Abstract

Perinatal brain injury is a major contributor to perinatal morbidity and mortality, and a considerable number of these children will develop long term neurodevelopmental disabilities. Despite the severe clinical and socio-economic significance and the advances in neonatal care over the past twenty years, no therapy yet exists that effectively prevents or ameliorates detrimental neurodevelopmental effects in cases of perinatal/neonatal brain injury. Our objective is to review recent evidence in relation to the pervading hypothesis for targeting time-dependent molecular and cellular repair mechanisms in the developing brain. In addition we review several potential neuroprotective strategies specific to the developing nervous system, with a focus on erythropoietin (Epo) because of its potential role in protection as well as repair.

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