Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Res. 2005 May;57(5 Pt 2):110R-117R. Epub 2005 Apr 6.

Potential for protection and repair following injury to the developing brain: a role for erythropoietin?

Author information

Division of Neonatal-Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.


Perinatal brain injury is a major contributor to perinatal morbidity and mortality, and a considerable number of these children will develop long term neurodevelopmental disabilities. Despite the severe clinical and socio-economic significance and the advances in neonatal care over the past twenty years, no therapy yet exists that effectively prevents or ameliorates detrimental neurodevelopmental effects in cases of perinatal/neonatal brain injury. Our objective is to review recent evidence in relation to the pervading hypothesis for targeting time-dependent molecular and cellular repair mechanisms in the developing brain. In addition we review several potential neuroprotective strategies specific to the developing nervous system, with a focus on erythropoietin (Epo) because of its potential role in protection as well as repair.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center