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Trends Biochem Sci. 2005 Apr;30(4):172-5.

Centromeric chromatin makes its mark.

Author information

1
Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK.

Abstract

Post-translational modifications of core histones, particularly in the N terminus, seem to define different chromatin states in the genome. For instance, actively transcribed regions of euchromatin have a completely different set of 'marks' compared with silent heterochromatin. Recent analyses surprisingly demonstrate that, in addition to containing the histone H3 variant CENP-A, the centromeric chromatin that underlies the kinetochore bears a distinct combination of histone H3 modifications.

PMID:
15817392
DOI:
10.1016/j.tibs.2005.02.007
[Indexed for MEDLINE]

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