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Methods Enzymol. 2005;393:524-39.

Peripheral clocks and the regulation of cardiovascular and metabolic function.

Author information

1
Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Abstract

Circadian rhythms generated by cell autonomous biological clocks allow for the appropriate temporal synchronization of physiology and behavior, optimizing the efficiency of biological systems. Circadian oscillators and functions have been uncovered in both central and peripheral tissues. This article describes methodology, experimental design, and technical challenges pertaining to studies of circadian rhythms in the periphery. Experimental approaches are focused upon revealing the role of peripheral clocks in cardiovascular and metabolic function using in vitro and in vivo techniques.

PMID:
15817310
DOI:
10.1016/S0076-6879(05)93027-9
[Indexed for MEDLINE]

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