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Org Lett. 2005 Apr 14;7(8):1449-51.

Asymmetric hydrogenation of isobutyrophenone using a [(Diphosphine) RuCl2 (1,4-diamine)] catalyst.

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1
Johnson Matthey Catalysis and Chiral Technologies, Unit 28, Cambridge Science Park, Milton Road, Cambridge, UK.

Abstract

[reaction: see text] The use of three chiral 1,4-diamines in the [(diphosphine) RuCl(2) (diamine)] catalyst system is demonstrated in the hydrogenation of acetophenone. The use of a 1,4-diamine offers unique properties that allow tuning of the catalyst system. These include the first example of the use of a racemic diamine in combination with a chiral phosphine, which gives 95% ee in the hydrogenation of isobutyrophenone.

PMID:
15816724
DOI:
10.1021/ol047355y
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