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J Clin Microbiol. 2005 Apr;43(4):1973-6.

Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates.

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1
Department of Clinical Microbiology, Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland.

Abstract

Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.

PMID:
15815035
PMCID:
PMC1081404
DOI:
10.1128/JCM.43.4.1973-1976.2005
[Indexed for MEDLINE]
Free PMC Article
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