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J Ethnopharmacol. 2005 Apr 26;98(3):335-8.

Effect of an avocado oil-rich diet over an angiotensin II-induced blood pressure response.

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Instituto Nacional de Cardiología Ignacio Chávez, Department of Pharmacology, Juan Badiano No. 1, Col. Sección XVI, Deleg. Tlalpan, Distrito Federal, C.P. 14080, México.


We studied the effect of an avocado oil-rich diet on (1) the blood pressure response to angiotensin II (AngII) and (2) the fatty acid composition of cardiac and renal membranes on male Wistar rats. The avocado oil-rich diet induced a slightly higher AngII-induced blood pressure response in the rats as compared to the control rats. In cardiac microsomes, avocado oil induced an increase in oleic acid content (13.18+/-0.33% versus 15.46+/-0.59%), while in renal microsomes, the oil decreased alpha-linolenic acid content (0.34+/-0.02% versus 0.16+/-0.12%), but increased the arachidonic acid proportion (24.02+/-0.54% versus 26.25+/-0.54%), compared to control. In conclusion, avocado oil-rich diet modifies the fatty acid content in cardiac and renal membranes in a tissue-specific manner. The rise in renal arachidonic acid suggests that diet content can be a key factor in vascular responses.

[Indexed for MEDLINE]

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