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Neuroreport. 2005 Apr 25;16(6):527-31.

Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis.

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  • 1Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98195-6465, USA.


Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and its animal models. A better understanding of neuroinflammation in motor neuron degeneration and amyotrophic lateral sclerosis disease progression promises to improve the rational design of greatly needed therapies.

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