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World J Gastroenterol. 2005 Apr 14;11(14):2162-5.

Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer.

Author information

1
Department of Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China. mingdong76@yahoo.com

Abstract

AIM:

To study the clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer.

METHODS:

To investigate the expression of p53 and mdm2 in pancreatic cancer by immunohistochemistry, and the relationships between the p53 and mdm2 protein expression and clinicopathological parameters in pancreatic cancer.

RESULTS:

The positive expression of p53 protein was found in 40 of 59 patients (67.8%) and that of mdm2 protein in 17 of 59 patients (28.8%). No obvious relationships were found between p53 as well as mdm2 expression and sex, tumor site, TNM staging and histological differentiation. p53 expression was increased in patients younger than 65 years old, while mdm2 had no relationship with age. The survival time of the patients with the positive expression of p53 and mdm2 proteins was obviously shorter than the other groups.

CONCLUSION:

Both p53 and mdm2 presented relatively high expression in human pancreatic cancer. The overexpression of p53 and mdm2 might reflect the malignant proliferation of pancreatic cancer and their co-expression might be helpful to evaluate the prognosis of the patients with pancreatic cancer.

PMID:
15810085
PMCID:
PMC4305788
DOI:
10.3748/wjg.v11.i14.2162
[Indexed for MEDLINE]
Free PMC Article

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