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Drug Discov Today. 2005 Mar 15;10(6):395-408.

Keynote review: epithelial and endothelial barriers in human disease.

Author information

1
Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA. mullinj@mlhs.org

Abstract

There is a spectrum of distinct disease states that have in common their effect of breaking down epithelial and/or endothelial barrier function. Fluid compartmentalization goes awry, with profound implications for epithelial and stromal homeostasis, fluid and/or electrolyte balance, generation of inflammatory states, and even tumor microenvironment. Specific effects on the tight junction are found to be integral to bacterial invasion and tumor progression.

PMID:
15808819
DOI:
10.1016/S1359-6446(05)03379-9
[Indexed for MEDLINE]

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