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Bioorg Med Chem Lett. 2005 Apr 15;15(8):2163-7.

Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. christopher_thompson@merck.com <christopher_thompson@merck.com>

Abstract

A series of novel ligands for the glucocorticoid receptor containing two heterocycles were synthesized. These compounds were investigated for a dissociative profile using transrepression and transactivation assays. Several compounds were tested in vivo and showed the ability to reduce inflammation in a mouse.

PMID:
15808489
DOI:
10.1016/j.bmcl.2005.02.009
[Indexed for MEDLINE]

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