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Trends Pharmacol Sci. 2005 Apr;26(4):190-5.

Mitochondrial nitric oxide synthase.

Author information

1
Department of Pharmacology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25704, USA. ghafourifar@marshall.edu

Abstract

Mitochondria produce nitric oxide (NO) through a Ca(2+)-sensitive mitochondrial NO synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via a reversible reaction with cytochrome c oxidase. The reaction of this NO with superoxide anion yields peroxynitrite, which irreversibly modifies susceptible targets within mitochondria and induces oxidative and/or nitrative stress. In this article, we review the current understanding of the roles of mtNOS as a crucial biochemical regulator of mitochondrial functions and attempt to reconcile apparent discrepancies in the literature on mtNOS.

PMID:
15808343
DOI:
10.1016/j.tips.2005.02.005
[Indexed for MEDLINE]

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