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Trends Pharmacol Sci. 2005 Apr;26(4):183-9.

Dual role of interactions between membranous and soluble portions of helical membrane receptors for folding and signaling.

Author information

1
Department of Pharmacology, University of Pittsburgh School of Medicine, Biomedical Science Tower E1058, 200 Lothrop St, Pittsburgh, PA 15261, USA. jks33@pitt.edu

Abstract

Dramatic advances in the understanding of the molecular mechanisms of membrane receptor activation for several prototypic members of different families of receptors have taken place during the past 2-3 years. The new structures of receptor fragments or full-length receptors in different conformations have been reviewed previously in light of the large bodies of available structure-function data. However, in this article, we will compare, among different receptor families, the emerging paradigms for conformational changes during signaling. Recent advances in the understanding of membrane-protein folding suggest that these paradigms are closely related to those that describe the folding and structural stability of membrane proteins. These relate in particular to long-range interactions not only within but also between soluble or membrane-embedded parts of proteins.

PMID:
15808342
DOI:
10.1016/j.tips.2005.02.009
[Indexed for MEDLINE]

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