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Trends Pharmacol Sci. 2005 Apr;26(4):178-82.

The efficiency of multi-target drugs: the network approach might help drug design.

Author information

1
Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest 8, Hungary. csermely@puskin.sote.hu

Abstract

Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single-target drugs did not increase appreciably during the past decade. Network models suggest that partial inhibition of a surprisingly small number of targets can be more efficient than the complete inhibition of a single target. This and the success stories of multi-target drugs and combinatorial therapies led us to suggest that systematic drug-design strategies should be directed against multiple targets. We propose that the final effect of partial, but multiple, drug actions might often surpass that of complete drug action at a single target. The future success of this novel drug-design paradigm will depend not only on a new generation of computer models to identify the correct multiple targets and their multi-fitting, low-affinity drug candidates but also on more-efficient in vivo testing.

PMID:
15808341
DOI:
10.1016/j.tips.2005.02.007
[Indexed for MEDLINE]

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