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Clin Exp Immunol. 2005 May;140(2):343-8.

Circulating YKL-40 levels during human endotoxaemia.

Author information

1
Department of Rheumatology Q107, University of Copenhagen, Herlev Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark. julia.johansen@post3.tele.dk

Abstract

YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia coli endotoxin or saline. Plasma YKL-40 increased after endotoxin injection from 31 microg/l (range 19-39 microg/l) to a maximum of 159 microg/l (61-552 microg/l, P < 0.01) at 24 h. The finding that plasma YKL-40 increased after endotoxin injection compared with saline (P < 0.001) suggests that YKL-40 has a functional role in infections.

PMID:
15807860
PMCID:
PMC1809363
DOI:
10.1111/j.1365-2249.2005.02763.x
[Indexed for MEDLINE]
Free PMC Article

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