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Lab Anim (NY). 2005 Apr;34(4):61-3.

Reestablishment of a transgenic rabbit line by artificial insemination using cryopreserved semen.

Author information

1
GTC Biotherapeutics, Spencer, MA 01562, USA. Stephen.Blash@gtc-bio.com

Abstract

The production of recombinant proteins in the milk of transgenic animals is an alternative to traditional cell culture methodology. Transgenic rabbits can serve in the small-scale production of recombinant proteins, underscoring the need to maintain valuable transgenic lines. In this study, the authors used cryopreserved transgenic rabbit semen to artificially inseminate does, demonstrating the utility of this method for the reestablishment of a transgenic rabbit herd.

PMID:
15806092
DOI:
10.1038/laban0405-61
[Indexed for MEDLINE]
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