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Otolaryngol Head Neck Surg. 2005 Apr;132(4):598-601.

Use of mitomycin C for treatment of keloid: a preliminary report.

Author information

1
Department of Otolaryngology--Head and Neck Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel. yoav.talmi@sheba.health.gov.il

Abstract

OBJECTIVES:

Mitomycin C (MC) is an anti-neoplastic agent with an anti-proliferative effect on fibroblasts. We set out to evaluate the effect of MC application following keloid excision.

STUDY DESIGN AND SETTING:

Patients with keloid in a tertiary referral center were enrolled in a prospective study. The scar was excised and prior to skin closure, a pledget with 1 cc of MC 0.4 mg/mL was applied for 5 minutes. Patient satisfaction and keloid thickness were assessed.

RESULTS:

All patients were satisfied with the results, although complete disappearance of the keloid was evident only in two. Keloid thickness was measured and ranged from 5 to 26 mm. Following surgery and treatment at 2 months thickness ranged from 0 to 8 mm.

CONCLUSIONS:

MC application following scar resection appears to be effective in treatment of keloid.

SIGNIFICANCE:

As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome.

PMID:
15806053
DOI:
10.1016/j.otohns.2004.09.060
[Indexed for MEDLINE]

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