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Nat Rev Neurosci. 2005 Apr;6(4):312-24.

Cortical inhibitory neurons and schizophrenia.

Author information

1
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. lewisda@upmc.edu

Abstract

Impairments in certain cognitive functions, such as working memory, are core features of schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA (gamma-aminobutyric acid) synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia. Despite both pre- and postsynaptic compensatory responses, the resulting alteration in perisomatic inhibition of pyramidal neurons contributes to a diminished capacity for the gamma-frequency synchronized neuronal activity that is required for working memory function. These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia.

PMID:
15803162
DOI:
10.1038/nrn1648
[Indexed for MEDLINE]
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