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Nat Rev Neurosci. 2005 Apr;6(4):297-311.

Anatomical and physiological foundations of cerebellar information processing.

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Sensorimotor Control Group, Department of Physiology, University of Bristol, University Walk, Bristol BS8 1TD, UK.


A coordinated movement is easy to recognize, but we know little about how it is achieved. In search of the neural basis of coordination, we present a model of spinocerebellar interactions in which the structure-functional organizing principle is a division of the cerebellum into discrete microcomplexes. Each microcomplex is the recipient of a specific motor error signal - that is, a signal that conveys information about an inappropriate movement. These signals are encoded by spinal reflex circuits and conveyed to the cerebellar cortex through climbing fibre afferents. This organization reveals salient features of cerebellar information processing, but also highlights the importance of systems level analysis for a fuller understanding of the neural mechanisms that underlie behaviour.

[Indexed for MEDLINE]

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