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Nat Rev Immunol. 2005 Apr;5(4):318-30.

Heat-shock proteins induce T-cell regulation of chronic inflammation.

Author information

1
Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands. w.eden@vet.uu.nl

Abstract

Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, HSPs can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory disease, HSP-derived peptides have been shown to promote the production of anti-inflammatory cytokines, indicating that HSPs have immunoregulatory potential. In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities.

PMID:
15803151
DOI:
10.1038/nri1593
[Indexed for MEDLINE]
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