Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2005 Apr;6(4):345-51.

Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis.

Author information

1
National Institute of Child Health and Human Development, Cell Biology and Metabolism Branch, Bethesda, Maryland 20892, USA. trou@helix.nih.gov

Abstract

Iron-sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formation of iron-sulphur clusters are widely conserved from bacteria to humans. Recent studies in model systems and humans reveal that iron-sulphur proteins have important roles in mitochondrial iron homeostasis and in the pathogenesis of the human disease Friedreich ataxia.

PMID:
15803140
DOI:
10.1038/nrm1620
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center