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Curr Opin Microbiol. 2005 Apr;8(2):168-73.

PII signal transduction proteins: sensors of alpha-ketoglutarate that regulate nitrogen metabolism.

Author information

1
Department of Biological Chemistry, University of Michigan Medical School, 1301 E. Catherine St., Ann Arbor, Michigan 48109-0606, USA. aninfa@umich.edu

Abstract

PII proteins are small homotrimeric signal transduction proteins that regulate the activities of metabolic enzymes and permeases, and control the activities of signal transduction enzymes. The protein family shows high conservation, with examples in eukaryota (plants and eukaryotic algae), archaea, and bacteria. This distribution indicates that PII is one of the most ancient signalling proteins known.

PMID:
15802248
DOI:
10.1016/j.mib.2005.02.011
[Indexed for MEDLINE]

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