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Semin Cell Dev Biol. 2005 Apr;16(2):155-61.

Sterol homeostasis in the budding yeast, Saccharomyces cerevisiae.

Author information

1
Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA.

Abstract

Lipid related diseases, such as obesity, type 2 diabetes, and atherosclerosis are epidemics in developed civilizations. A common underlying factor among these syndromes is excessive subcellular accumulation of lipids such as cholesterol and triglyceride. The homeostatic events that govern these metabolites are understood to varying degrees of sophistication. We describe here the utilization of a genetically powerful model organism, budding yeast, to identify and characterize novel aspects of sterol and lipid homeostasis.

PMID:
15797826
DOI:
10.1016/j.semcdb.2005.01.006
[Indexed for MEDLINE]

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