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Trends Genet. 2005 Apr;21(4):207-10.

Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes.

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IGBMC, 1 rue Laurent Fries, BP 10142 67404 Illkirch Cedex, France.

Abstract

Sequence conservation has been used to find genes and to pinpoint functional non-coding sequences such as transcriptional regulatory elements. In this article, we analysed the conservation of 104 experimentally validated murine enhancer sequences between the mouse and zebrafish genomes. Surprisingly, only 10.5% of the mouse enhancers have homologues in zebrafish. All of the genes with conserved cis-elements have regulatory functions during embryonic development, perhaps reflecting substantial structural constraints on the integration of spatio-temporal signalling cues during the formation of the vertebrate body.

PMID:
15797614
DOI:
10.1016/j.tig.2005.02.006
[Indexed for MEDLINE]
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