Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2005 Apr;15(2):116-24.

Transcriptional regulation by the numbers: models.

Author information

1
Physics Department, Brandeis University, Waltham, MA 02454, USA.

Abstract

The expression of genes is regularly characterized with respect to how much, how fast, when and where. Such quantitative data demands quantitative models. Thermodynamic models are based on the assumption that the level of gene expression is proportional to the equilibrium probability that RNA polymerase (RNAP) is bound to the promoter of interest. Statistical mechanics provides a framework for computing these probabilities. Within this framework, interactions of activators, repressors, helper molecules and RNAP are described by a single function, the "regulation factor". This analysis culminates in an expression for the probability of RNA polymerase binding at the promoter of interest as a function of the number of regulatory proteins in the cell.

PMID:
15797194
PMCID:
PMC3482385
DOI:
10.1016/j.gde.2005.02.007
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center