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Expert Opin Drug Saf. 2005 Mar;4(2):219-34.

Toxicity of the topoisomerase II inhibitors.

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New York Medical College, Room 250 Munger Pavilion, Valhalla, New York 10595, USA.


Topoisomerase II inhibitors represent a broad class of antineoplastic agents with a wide spectrum of activity against malignancies. Topoisomerase II inhibitors include the anthracyclines, mitoxantrone and epipodophyllotoxins. Short-term toxicity includes myelosuppression and gastrointestinal toxicity. Long-term survivors are at risk of cardiac toxicity and secondary leukaemia. This article discusses these toxicities in detail, including administration of these agents to patients with hepatic and/or renal insufficiency, and the need for dose adjustments in selected patient populations.

[Indexed for MEDLINE]

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