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Nat Genet. 2005 Apr;37(4):349-50. Epub 2005 Mar 27.

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

Author information

1
Institut National de la Santé et de la Recherche Médicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France.

Erratum in

  • Nat Genet. 2005 May;37(5):555.

Abstract

We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.

Comment in

PMID:
15793589
DOI:
10.1038/ng1534
[Indexed for MEDLINE]

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