The purposes of this study were to examine gender differences in happiness; to examine the relationship between happiness and several health variables, such as perceived health status, clinical health, and wellness, in early adolescents; and to examine further these relationships for boys and girls separately. The final sample consisted of 151 early adolescent boys and girls who were in the seventh and eighth grades of an urban middle school. Students responded to instruments measuring happiness, perceived health status, clinical health, and wellness. Results indicated there were no gender differences in happiness between boys and girls. Statistically significant positive correlations were found between happiness and the health-related variables for the entire sample, with different patterns of relationships when boys and girls were analyzed separately. The application of findings to nursing is discussed.