Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2005 Apr;49(4):1649-51.

Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.

Author information

1
Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195. labauer@u.washington.edu.

Abstract

Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

PMID:
15793163
PMCID:
PMC1068590
DOI:
10.1128/AAC.49.4.1649-1651.2005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center