Format

Send to

Choose Destination
See comment in PubMed Commons below
Antimicrob Agents Chemother. 2005 Apr;49(4):1600-3.

Impact of clarithromycin resistance on eradication of Helicobacter pylori in infected adults.

Author information

1
Research Center for Gastroenterology, Dankook University College of Medicine, Cheonan, Choongnamdo, Republic of Korea.

Abstract

The outcome of Helicobacter pylori infection was analyzed in 114 dyspeptic patients treated with triple-drug therapy including clarithromycin. Clarithromycin resistance (in 20.2% of our isolates) was mainly caused by an A2142G mutation in the 23S rRNA gene of H. pylori. H. pylori eradication was obtained in all patients with clarithromycin-susceptible isolates but not in any patients with clarithromycin-resistant isolates (P = 0.0001). Therefore, it would be useful to conduct H. pylori antimicrobial susceptibility testing of the first gastric biopsy culture before choosing the first three drugs for therapy of infected patients.

PMID:
15793150
PMCID:
PMC1068646
DOI:
10.1128/AAC.49.4.1600-1603.2005
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center