Format

Send to

Choose Destination
FEBS Lett. 2005 Mar 28;579(9):1978-82.

Cold exposure differently influences mitochondrial energy efficiency in rat liver and skeletal muscle.

Author information

1
Department of Biological Sciences, Section of Physiology, University of Naples "Federico II", Via Mezzocannone 8, I-80134 Naples, Italy.

Abstract

This study deals with mitochondrial energy efficiency in liver and skeletal muscle mitochondria in 15 days cold exposed rats. Cold exposure strongly increases the sensitivity to uncoupling by added palmitate of skeletal muscle but not liver mitochondria, while mitochondrial energy coupling in the absence of fatty acids is only slightly affected by cold in liver and skeletal muscle. In addition, uncoupling protein 3 content does not follow changes in skeletal muscle mitochondrial coupling. It is therefore concluded that skeletal muscle could play a direct thermogenic role based on fatty acid-induced mild uncoupling of mitochondrial oxidative phosphorylation.

PMID:
15792806
DOI:
10.1016/j.febslet.2005.02.044
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center