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Lancet Infect Dis. 2005 Apr;5(4):209-18.

Mechanisms of action of newer antibiotics for Gram-positive pathogens.

Author information

1
University of British Columbia, Vancouver, British Columbia, Canada. bob@cmdr.ubc.ca

Abstract

Certain Gram-positive bacteria, including meticillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and quinolone-resistant Streptococcus pneumoniae have achieved the status of "superbugs", in that there are few or no antibiotics available for therapy against these pathogens. Only a few classes of novel antibiotics have been introduced in the past 40 years, and all since 1999, including the streptogramin combination quinupristin/dalfopristin (Synercid), the oxazolidinone linezolid, and the lipopeptide daptomycin. This review discusses the mechanisms of antibiotic action against Gram-positive pathogens, and resistance counter-mechanisms developed by Gram-positive bacteria, with emphasis on the newer agents.

PMID:
15792738
DOI:
10.1016/S1473-3099(05)70051-7
[Indexed for MEDLINE]

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