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Nano Lett. 2005 Jan;5(1):157-61.

Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats.

Author information

1
Graduate School of Dental Medicine, Hokkaido University, Japan. yokoyama@den.hokudai.ac.jp

Abstract

The tissue response to hat-stacked carbon nanofibers (H-CNFs) was evaluated. H-CNFs were implanted in the subcutaneous tissue of rats. Histological and ultrastructural investigations were carried out by transmission electron microscopy. Although many macrophages and foreign body giant cells were seen around H-CNFs, no severe inflammatory response such as necrosis was observed. Some H-CNFs were observed in lysosomal vacuoles of phagocytes. These results showed that H-CNFs were not strong prophlogistic substances and were englobed in vivo.

PMID:
15792431
DOI:
10.1021/nl0484752
[Indexed for MEDLINE]

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