Composite organic-inorganic nanoparticles (COINs) with chemically encoded optical signatures

Xing Su; Jingwu Zhang; Lei Sun; Tae-Woong Koo; Selena Chan; Narayan Sundararajan; Mineo Yamakawa; Andrew A Berlin

doi:10.1021/nl0484088

Composite organic-inorganic nanoparticles (COINs) with chemically encoded optical signatures

Nano Lett. 2005 Jan;5(1):49-54. doi: 10.1021/nl0484088.

Authors

Xing Su¹, Jingwu Zhang, Lei Sun, Tae-Woong Koo, Selena Chan, Narayan Sundararajan, Mineo Yamakawa, Andrew A Berlin

Affiliation

¹ Biotechnology Research Group, Intel Research and CTM, Intel Corporation, SC2-24, 2200 Mission College Boulevard, Santa Clara, California 95054, USA. xing.su@intel.com

PMID: 15792411
DOI: 10.1021/nl0484088

Abstract

To obtain a coding system for multiplex detection, we have developed a method to synthesize a new type of nanomaterial called composite organic-inorganic nanoparticles (COINs). The method allows the incorporation of a broad range of organic compounds into COINs to produce surface enhanced Raman scattering (SERS)-like spectra that are richer in variety than fluorescence-based signatures. Preliminary data suggest that COINs can be used as Raman tags for multiplex and ultrasensitive detection of biomolecules.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gold / chemistry*
Immunoassay
Interleukin-2 / analysis
Interleukin-8 / analysis
Microscopy, Electron, Transmission
Nanostructures / chemistry*
Nitrates / chemistry
Organic Chemicals / chemistry*
Sensitivity and Specificity
Silver / chemistry*
Silver Nitrate / chemistry
Spectrum Analysis, Raman / methods*

Substances

Interleukin-2
Interleukin-8
Nitrates
Organic Chemicals
Silver
Gold
sodium nitrate
Silver Nitrate