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Nano Lett. 2005 Jan;5(1):45-8.

Amphiphilic network as nanoreactor for enzymes in organic solvents.

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1
Freiburg Materials Research Center (FMF) and Institute of Macromolecular Chemistry, Albert-Ludwigs-University Freiburg, Stefan-Meier-Strasse 21, 79104 Freiburg, Germany.

Abstract

Enzymes are powerful biocatalysts that work naturally in water but are also active in organic solvents. Here, we present a nanophase-separated amphiphilic network, where an enzyme is entrapped into its hydrophilic domains. A substrate that diffuses into the other, hydrophobic, phase of such a network can access the biocatalyst via the extremely large interface. Entrapped horseradish peroxidase and chloroperoxidase showed dramatically increased activity and operational stability compared to the native enzymes.

PMID:
15792410
DOI:
10.1021/nl048413b
[Indexed for MEDLINE]
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