Format

Send to

Choose Destination
Science. 2005 Mar 25;307(5717):1955-9.

Glycan foraging in vivo by an intestine-adapted bacterial symbiont.

Author information

1
Center for Genome Sciences, Washington University, St. Louis, MO 63108, USA.

Abstract

Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity.

PMID:
15790854
DOI:
10.1126/science.1109051
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center