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Drug Resist Updat. 2004 Dec;7(6):321-4. Epub 2005 Jan 11.

Cancer cell death by programmed necrosis?

Author information

1
Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

Abstract

A recent paper by Zong et al. describes how alkylating agents kill cells by a process they term "programmed necrosis," induced by excessive activation of PARP resulting in degradation of cytosolic NAD(+) and inhibition of glycolysis. We argue that it is not obvious whether chemotherapy in patients can induce sufficient NAD(+) loss to affect glycolysis; that the "programmed" nature of the necrosis requires more evidence; and that there are mechanisms making cancer cells hypersensitive to DNA damage other than their high rate of aerobic glycolysis.

PMID:
15790542
DOI:
10.1016/j.drup.2004.11.003
[Indexed for MEDLINE]

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