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Prostaglandins Other Lipid Mediat. 2005 Jan;75(1-4):169-72.

A phase I study of 5-fluorouracil, leucovorin, and celecoxib in patients with incurable colorectal cancer.

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Oregon Health and Science University Cancer Institute, Portland, OR, USA.


A phase I study of fixed-dose 5-fluorouracil (FU) and leucovorin (LCV), with excalating doses of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, was conducted in 16 patients with advanced colorectal adenocarcinoma. At doses typically used to treat arthritis patients (100-200 mg po BID), celecoxib did not increase toxicities expected from the chemotherapy alone. 5-FU and leucovorin did not affect COX-2 inhibition by celecoxib. Preliminary data suggest it is safe to combine celecoxib with standard chemotherapeutic agents, in treatment of patients with colorectal cancer.

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