Origin of Aymaras from Bolivia and their relationship with other Amerindians according to HLA genes

A Arnaiz-Villena; N Siles; J Moscoso; J Zamora; J I Serrano-Vela; E Gomez-Casado; M J Castro; J Martinez-Laso

doi:10.1111/j.1399-0039.2005.00356.x

Origin of Aymaras from Bolivia and their relationship with other Amerindians according to HLA genes

Tissue Antigens. 2005 Apr;65(4):379-90. doi: 10.1111/j.1399-0039.2005.00356.x.

Authors

A Arnaiz-Villena¹, N Siles, J Moscoso, J Zamora, J I Serrano-Vela, E Gomez-Casado, M J Castro, J Martinez-Laso

Affiliation

¹ Department of Immunology, Universidad Complutense, Madrid, Spain. aarnaiz@med.ucm.es

PMID: 15787722
DOI: 10.1111/j.1399-0039.2005.00356.x

Abstract

Aymara Amerindians from the Titicaca Lake Andean highlands are studied for HLA-A, HLA-B, HLA-DRB1 and HLA-DQB1 gene frequencies. Genetic distances, neighbour-joining and correspondence analyses are performed by using other Amerindian and worldwide populations (15384 chromosomes are studied). The HLA genetic profile of Aymaras is different from neighbouring and language-related Quechuas (Incas). Both Quechuas and Aymaras seem to present an HLA-DRB1*0901 high frequency, which is present in a very low frequency or absent in Mesoamericans (Mazatecans, Mayans) and most studied Amerindians. Moreover, it is observed a closer relatedness of Aymaras with Amerindians from the Amazon Basin and Chaco lowlands, compared to Quechuans.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

American Indian or Alaska Native / genetics*
Bolivia
Gene Frequency
HLA Antigens / genetics*
Haplotypes
Histocompatibility Antigens Class I / genetics*
Histocompatibility Antigens Class II / genetics*
Humans

Substances

HLA Antigens
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II