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J Am Chem Soc. 2005 Mar 30;127(12):4158-9.

Cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase activity.

Author information

  • 1Department of Radiology, Biophysics, Bio-X, Cancer Biology, and Molecular Imaging Programs at Stanford, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5344, USA.

Erratum in

  • J Am Chem Soc. 2006 Feb 1;128(4):1394.

Abstract

This communication describes a design of cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase expression in living mammalian cells. This design is based on fluorescence energy transfer resonance and utilizes a peracetylated d-glucosamine to facilitate the transport of the near-infrared probe across cell membranes. This new type of fluorogenic probe may also be applied to image gene expression in living animals.

PMID:
15783183
DOI:
10.1021/ja042829+
[PubMed - indexed for MEDLINE]
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