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J Am Chem Soc. 2005 Mar 30;127(12):4140-1.

(+)-Myristinin A, a naturally occurring DNA polymerase beta inhibitor and potent DNA-damaging agent.

Author information

1
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901, USA.

Abstract

The first stereoselective total synthesis of the naturally occurring flavan myristinin A has been accomplished, as well as its biochemical evaluation. This synthesis verified the structural assignment and allowed for the determination of the absolute stereochemistry. Myristinin A exhibits biochemical activity both as a potent DNA-damaging agent and DNA polymerase beta inhibitor. Relaxation of supercoiled plasmid DNA was observed at picomolar concentrations, in addition to inhibition of polymerase beta at low micromolar concentrations.

PMID:
15783174
DOI:
10.1021/ja042727j
[Indexed for MEDLINE]

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