Abstract
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.
MeSH terms
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Animals
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Antigens, CD
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Cell Communication / physiology
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Cell Differentiation / physiology*
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Glycoproteins / metabolism
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Humans
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Immunoglobulins / metabolism
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Intracellular Signaling Peptides and Proteins / metabolism*
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Killer Cells, Natural / physiology*
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Proto-Oncogene Proteins / metabolism*
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Proto-Oncogene Proteins c-fyn
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Receptors, Cell Surface
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Signal Transduction / physiology*
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Signaling Lymphocytic Activation Molecule Associated Protein
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Signaling Lymphocytic Activation Molecule Family Member 1
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T-Lymphocytes / physiology*
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Thymus Gland / physiology
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src-Family Kinases / metabolism*
Substances
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Antigens, CD
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Glycoproteins
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Immunoglobulins
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Intracellular Signaling Peptides and Proteins
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Proto-Oncogene Proteins
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Receptors, Cell Surface
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SH2D1A protein, human
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Signaling Lymphocytic Activation Molecule Associated Protein
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Signaling Lymphocytic Activation Molecule Family Member 1
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FYN protein, human
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Proto-Oncogene Proteins c-fyn
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src-Family Kinases