Signaling for NKT cell development: the SAP-FynT connection

J Exp Med. 2005 Mar 21;201(6):833-6. doi: 10.1084/jem.20050339.

Abstract

New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • Cell Communication / physiology
  • Cell Differentiation / physiology*
  • Glycoproteins / metabolism
  • Humans
  • Immunoglobulins / metabolism
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Killer Cells, Natural / physiology*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-fyn
  • Receptors, Cell Surface
  • Signal Transduction / physiology*
  • Signaling Lymphocytic Activation Molecule Associated Protein
  • Signaling Lymphocytic Activation Molecule Family Member 1
  • T-Lymphocytes / physiology*
  • Thymus Gland / physiology
  • src-Family Kinases / metabolism*

Substances

  • Antigens, CD
  • Glycoproteins
  • Immunoglobulins
  • Intracellular Signaling Peptides and Proteins
  • Proto-Oncogene Proteins
  • Receptors, Cell Surface
  • SH2D1A protein, human
  • Signaling Lymphocytic Activation Molecule Associated Protein
  • Signaling Lymphocytic Activation Molecule Family Member 1
  • FYN protein, human
  • Proto-Oncogene Proteins c-fyn
  • src-Family Kinases