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Am J Cardiol. 2005 Apr 1;95(7):915-8.

Impact of methadone treatment on cardiac repolarization and conduction in opioid users.

Author information

1
Section of General Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. bridget.martell@yale.edu

Abstract

We prospectively assessed the effect of oral methadone on the corrected QT interval (QTc) among 160 patients free of structural heart disease and measured serum methadone concentrations and simultaneous QTc intervals in a subset of 44 participants. Mean +/- SD QTc increased by 12.4 +/- 23 ms (p <0.001) at 6 months, by 10.7 +/- 30 ms (p <0.001) at 12 months, and the QTc change from baseline to 12 months correlated with the trough (r = 0.37, p = 0.008) and peak (r = 0.32, p = 0.03) serum methadone concentrations.

PMID:
15781034
DOI:
10.1016/j.amjcard.2004.11.055
[Indexed for MEDLINE]

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