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Crit Rev Oncol Hematol. 2005 Apr;54(1):1-10.

Chemoprevention of prostate cancer.

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1
Section of Urologic Oncology, Glickman Urological Institute, Cleveland, OH 44195, USA. kleine@ccf.org

Abstract

Prostate cancer is an attractive target for chemoprevention because of its ubiquity, treatment-related morbidity, long latency between premalignant lesions and clinically evident cancer, and defined molecular pathogenesis. Prevention of this disease would have a major impact on disease-associated cost, morbidity, and mortality for a large segment of the population. A major advance in prevention of prostate cancer came in 2003 with the publication of the Prostate Cancer Prevention Trial (PCPT). This overview summarizes the results of that trial, the design of other large-scale trials, and advances in understanding of the molecular mechanisms underlying the effect of other promising agents, including dutasteride, selenium, Vitamin E, Vitamin D, COX-2 inhibitors, lycopene, and green tea.

[Indexed for MEDLINE]

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