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Curr Opin Cell Biol. 2005 Apr;17(2):123-8.

Linking Rap to cell adhesion.

Author information

  • 1Department of Physiological Chemistry and Centre for Biomedical Genetics, UMC Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands. j.l.bos@med.uu.nl

Abstract

The small GTPase Rap1 is involved in several aspects of cell adhesion, including integrin-mediated cell adhesion and cadherin-mediated cell junction formation. Recently, several effector proteins for Rap1 have been identified providing a clear link between Rap1 and actin dynamics. Furthermore, evidence is accumulating that Rap1 functions in the spatial and temporal control of cell polarity.

PMID:
15780587
DOI:
10.1016/j.ceb.2005.02.009
[PubMed - indexed for MEDLINE]
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