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Curr Opin Cell Biol. 2005 Apr;17(2):107-11.

Compartmentalization of growth factor receptor signalling.

Author information

1
Institute for Biochemistry II, University Hospital of Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

Abstract

Spatial and temporal separation of signal transduction pathways often determines the specificity in cellular responses. Recent advances have improved our understanding of how growth factor signalling is influenced by the formation of molecular complexes (signalosomes) in distinct cellular compartments. There has also been new insight into the mechanisms that determine the signalling competence of these complexes and their role in receptor endocytosis, retrograde trafficking in neurons and restricted protein biosynthesis, and many examples have been found where signalosome deregulation leads to disease.

PMID:
15780584
DOI:
10.1016/j.ceb.2005.01.001
[Indexed for MEDLINE]

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