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J Natl Med Assoc. 2005 Mar;97(3):329-33.

Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females.

Author information

1
Divisions of General Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA. kaganesa@cdrewu.edu

Abstract

OBJECTIVE:

Inflammatory cytokines have been shown to play an important role in bone remodeling. We hypothesized that higher levels of C-reactive protein (CRP) are associated with low bone mineral density (BMD) in elderly females.

DESIGN:

Secondary data analysis of the Third National Health and Nutrition Examination Survey.

PARTICIPANTS:

2,807 females 65 years and older.

RESULTS:

CRP was associated with BMD in the bivariate sis (p<0.001) but not in the multivariate analysis (p=0.23) Age, ethnicity, body mass index (BMI), hormone replacement therapy (HRT) and immobility were independently associated with BMD.

CONCLUSIONS:

CRP may be useful in screening for osteoporosis among community-dwelling elderly females. However, CRP appears to act as a surrogate for other factorsdirectly associated with osteoporosis. Further studies are needed to validate these findings.

PMID:
15779496
PMCID:
PMC2568626
[Indexed for MEDLINE]
Free PMC Article
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