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Microbes Infect. 2005 Mar;7(3):529-36. Epub 2005 Feb 3.

Murine gammadelta T cells in infections: beneficial or deleterious?

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School of Biochemistry and Microbiology, The University of Leeds, Leeds LS2 9JT, UK.


Although the importance of gammadelta T cells in pathogen-induced immune responses is becoming increasingly apparent, it is not clear that their involvement is always of benefit to the host. Here we review evidence for the protective and damaging roles of gammadelta T cells in infection and discuss how these disparate findings might be resolved by considering the nature and properties of the pathogen, the sites of infection and conditions under which gammadelta T cell responses are initiated, and the involvement of different subsets of gammadelta T cells.

[Indexed for MEDLINE]

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