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J Antibiot (Tokyo). 1992 Mar;45(3):325-30.

A new tetracycline antibiotic with antitumor activity. II. The structural elucidation of SF2575.

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1
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.

Abstract

The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicyclic acid and angelic acid moieties.

PMID:
1577661
DOI:
10.7164/antibiotics.45.325
[Indexed for MEDLINE]
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