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Neuropediatrics. 2005 Feb;36(1):40-4.

Cerebral thrombotic microangiopathy and antiphospholipid antibodies in Aicardi-Goutieres syndrome--report of two sisters.

Author information

1
Department of Pediatrics, Rikshospitalet, Oslo, Norway. magnhild.rasmussen@rikshospitalet.no

Abstract

Cerebral thrombotic microangiopathy was found at autopsy in one of two sisters with Aicardi-Goutieres syndrome, whereas the other revealed increased serum levels of anticardiolipin IgG antibodies (measured only in the living sister); both typical features of systemic lupus erythematosus. These findings add support to the suggestion that Aicardi-Goutieres syndrome and systemic lupus erythematosus are closely related disorders in which dysregulated production of interferon-alpha might play a crucial role.

PMID:
15776321
DOI:
10.1055/s-2004-830532
[Indexed for MEDLINE]

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