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Nat Rev Cancer. 2005 Apr;5(4):263-74.

Immunosuppressive networks in the tumour environment and their therapeutic relevance.

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1
Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112-2699, USA. wzou@tulane.edu

Abstract

It is well known that many tumours are potentially immunogenic, as corroborated by the presence of tumour-specific immune responses in vivo. Nonetheless, spontaneous clearance of established tumours by endogenous immune mechanisms is rare. Therefore, the focus of most cancer immunotherapies is to supplement essential immunogenic elements to boost tumour-specific immunity. Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity.

PMID:
15776005
DOI:
10.1038/nrc1586
[Indexed for MEDLINE]
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